A Prospective Analysis of Laboratory Tests and Imaging Studies To Detect Hepatic Lesions
Year: 1982
Type: article
Study design: Observational Study
Abstract: A prospective study of the ability of laboratory tests and liver imaging tests to detect hepatic metastases was performed. Eighty patients at risk for hepatic metastases but without clinical evidence of disease were tested with 13 laboratory tests and three liver imaging tests. No single laboratory test had greater than 65% accuracy in the detection of hepatic lesions. No combination of the laboratory tests increased this accuracy. If the laboratory tests were used with one of the liver imaging tests, the accuracy was improved in some combinations to 76%. The CEA assay when analyzed in patients with colorectal primaries had an accuracy of 79%. The results show that the laboratory tests alone are not sufficiently accurate to detect liver metastases. Additional accuracy can be obtained by the combined use of a single liver imaging test and selected laboratory tests. Use of all the liver imaging tests and laboratory tests lowers the accuracy and increases the expense and thus is unnecessary.
Source: Annals of Surgery
Authors: MARY MARGARET KEMENY, PAUL H. SUGARBAKER, THOMAS J. SMITH, BRENDA K. EDWARDS, THOMAS SHAWKER, MICHAEL VERMESS, A. ERIC JONES
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2005445925