Year: 2015
Type: review
Abstract: Nanoparticulate delivery systems represent an area of particular promise for nanoneuromedicines. They possess significant potential for desperately needed therapies designed to combat a range of disorders associated with aging. As such, the field was selected as the focus for the 2014 meeting of the American Society for Nanomedicine. Regenerative, protective, immune modulatory, anti-microbial and anti-inflammatory products, or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the blood-brain barrier. Diagnostic imaging serves to precisely monitor disease onset and progression while neural stem cell replacement can regenerate damaged tissue through control of stem cell fates. These, taken together, can improve disease burden and limit systemic toxicities. Such enabling technologies serve to protect the nervous system against a broad range of degenerative, traumatic, metabolic, infectious and immune disorders. From the clinical editor: Nanoneuromedicine is a branch of nanomedicine that specifically looks at the nervous system. In the clinical setting, a fundamental hurdle in nervous system disorders is due to an inherent inability of nerve cells to regenerate after damage. Nanotechnology can offer new approaches to overcome these challenges. This review describes recent developments in nanomedicine delivery systems that would affect stem cell repair and regeneration in the nervous system.
Institutions: Iowa State University, University of Nebraska Medical Center
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,670
Funders: University of Nebraska Medical Center, Iowa State University, ViiV Healthcare, National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke
Awards: G1398244641, NanoART Manufacture, Delivery and Pharmacokinetics for Optimizing Drug Adherence, G2585785709, Neuronanomedicine, G3283595100, Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center, Nanomedicine and NeuroAIDS, Novel Adjunctive Therapies for NeuroAIDS, Molecular Mechanisms of HIV-1 Associated Encephalopathy, G5850682332, Nebraska Center for Nanomedicine, SMART HAND, Novel Kinase and Nanoformulated Protease Inhibitors for Eradication of CNS HIV-1, Neural Immunity in HIV Dementia, Neuroprotective Immunity and HIV Dementia, G9000262396, G9000346257, G9000352132
OpenAlex ID: W2005510687