Work

Selective Loss of [3H]Kainic Acid and [3H]AMPA Binding in Layer VI of Frontal Cortex in Huntington's Disease

Year: 1994

Type: article

Abstract: Excitatory amino acid neurotoxicity has been proposed to cause the neostriatal neuronal degeneration of Huntington's disease (HD); N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), and kainate receptors have been hypothesized to play important roles in this process. We have recently reported a loss of neurons in layer VI of the cerebral cortex in HD. Using quantitative autoradiographic methods, we have now measured NMDA, AMPA, and kainate receptor binding in the frontal cerebral cortex of the brains of controls and individuals with HD. We find no change in NMDA receptor binding but a selective decrease in kainate and AMPA receptor binding in layer VI. These data suggest that cerebral cortical neurons possessing kainate or AMPA receptors may be selectively vulnerable in individuals with HD.

Source: Experimental Neurology

DOI: 10.1006/exnr.1994.1081

Authors: Molly V. Wagster, John C. Hedreen, Carol E. Peyser, Susan E. Folstein, Christopher A. Ross

Institutions: Johns Hopkins University, VA Palo Alto Health Care System, Johns Hopkins Medicine

Language: English

Topic: Genetic Neurodegenerative Diseases

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,110