Work

End-Functionalized ROMP Polymers for Biomedical Applications

Year: 2010

Type: article

Abstract: We present two novel allyl-based terminating agents that can be used to end-functionalize living polymer chains obtained by ring-opening metathesis polymerization (ROMP) using Grubbs' third generation catalyst. Both terminating agents can be easily synthesized and yield ROMP polymers with stable, storable activated ester groups at the chain-end. These end-functionalized ROMP polymers are attractive building blocks for advanced polymeric materials, especially in the biomedical field. Dye-labeling and surface-coupling of antimicrobially active polymers using these end-groups were demonstrated.

Source: Macromolecules

DOI: 10.1021/ma100330u

Authors: Ahmad E. Madkour, Amelie H. R. Koch, Karen Lienkamp, Gregory N. Tew

Institution: University of Massachusetts Amherst

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, Office of Naval Research, National Institute of Allergy and Infectious Diseases

Awards: Design and mechanistic studies of mimics of antimicrobial peptides, Design and mechanistic studies of mimics of antimicrobial peptides, Antimicrobial Oligomers for BioDefense and Emerging Food Borne Infectious Disease