Work

Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA.

Year: 1992

Type: article

Abstract: Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.89.12.5680

Authors: J Normanly, T Ollick, J Abelson

Institution: California Institute of Technology

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G7091493455