Work

Clinical States Model for Biomarkers in Bladder Cancer

Year: 2009

Type: article

Abstract: Bladder cancer is a significant healthcare problem in the USA, with a high recurrence rate, the need for expensive continuous surveillance and limited treatment options for patients with advanced disease. Research has contributed to an understanding of the molecular pathways involved in the development and progression of bladder cancer, and that understanding has led to the discovery of potentially diagnostic, predictive and prognostic biomarkers. In this review, a clinical states model of bladder cancer is introduced and integrated into a paradigm for biomarker development. Biomarkers are systematically incorporated with predefined end points to aid in clinical management.

Source: Future Oncology

DOI: 10.2217/fon.09.57

Authors: Andrea B Apolo, Matthew Milowsky, Dean F Bajorin

Institutions: Memorial Sloan Kettering Cancer Center, Cornell University, Weill Cornell Medicine

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute