3D viability imaging of tumor phantoms treated with single-walled carbon nanohorns and photothermal therapy
Year: 2013
Type: article
Abstract: A new image analysis method called the spatial phantom evaluation of cellular thermal response in layers (SPECTRL) is presented for assessing spatial viability response to nanoparticle enhanced photothermal therapy in tissue representative phantoms. Sodium alginate phantoms seeded with MDA-MB-231 breast cancer cells and single-walled nanohorns were laser irradiated with an ytterbium fiber laser at a wavelength of 1064 nm and irradiance of 3.8 W cm(-2) for 10-80 s. SPECTRL quantitatively assessed and correlated 3D viability with spatiotemporal temperature. Based on this analysis, kill and transition zones increased from 3.7 mm(3) and 13 mm(3) respectively to 44.5 mm(3) and 44.3 mm(3) as duration was increased from 10 to 80 s. SPECTRL provides a quantitative tool for measuring precise spatial treatment regions, providing information necessary to tailor therapy protocols.
Source: Nanotechnology
Institution: Virginia Tech
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Awards: Trimetallic Nitride Templated Endohedral Metallofullerenes as Dual Imaging and Mu, G214517448, G25200180, Fiberoptic Microneedle Device for Nanoparticle-Enhanced Photothermal Therapy of A, Fiberoptic Microneedle Device for Combined Light and Nanomedicine Delivery: Mimicking Nature's Design of a Mosquito, Characterization and Model Development for the Cellular Response to Nanotube-Mediated Laser Therapy, CAREER: "Holey Scaffold" Sensing System for Characterization of the Spatiotemporal Tumor Response to Nanoparticle-Mediated Photothermal and Photochemical Therapy, Nanotubes in tumor imaging and therapy
OpenAlex ID: W2005956058