Year: 2009
Type: article
Abstract: Non-invasive in vivo cellular imaging with MRI has greatly broadened our understanding in many cellular and molecular processes, as well as in monitoring stem cell therapy. The target cells can be made MRI-detectable by labeling them with iron-oxide contrast agents, such as micrometer-sized-iron-oxide (MPIO) particles. With sufficient iron loading per cell, it is possible to detect single cells in vivo with MRI. However, motion artifacts and the need for gated acquisition have made imaging cells in the heart more challenging and time-consuming. The goal of this study is to develop a strategy to enable real-time imaging of individual labeled cells without the need for a gated or breath-hold protocol. To this end, we have implemented a new model-based imaging scheme for high-resolution free-breathing imaging, using the Partially Separable Function (PSF) model.
Authors: Yijen L Wu, Cornelius Brinegar, Zhi-Pei Liang, Qing Ye, T Kevin Hitchens, Lesley M Foley, Chien Ho
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,000
OpenAlex ID: W2005976785