Work

Molecular Regulation of Hepatic Dendritic Cell Function and Its Relation to Liver Transplant Outcome

Year: 2009

Type: review

Abstract: Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular regulators of signal transduction and of cytokines in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC. Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome.

Source: Transplantation

DOI: 10.1097/tp.0b013e3181af7c0d

Authors: Tina L. Sumpter, John G. Lunz, A Jake Demetris, Angus W. Thomson

Institution: University of Pittsburgh

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases