Year: 2008
Type: article
Abstract: Recent studies have proposed that chronic treatment with antidepressants increases neurogenesis in the adult hippocampus. This increase in the production of new neurons may be required for the behavioral effects of antidepressants. However, the effect of antidepressants does not define well in fetal neural stem cells. Fetal neural stem cells are derived from the fetal cerebral cortex of a 6∼7-weeks-old pregnant (13 days) C57BL/6 mice. In the present study, we examined the in vitro effects of antidepressant, the serotonin transporter inhibitor ‘fluoxetine’ on the survival, proliferation, and differentiation in fetal neural stem cells. Results here show fluoxetine's role in the proliferation and neural differentiation of fetal neural stem cells (NSCs) based on its degree of concentration. Nano M level of fluoxetine stimulated proliferation of NSCs and increased the number of Tuj1 positive cells, suggesting a role in activation of neuronal differentiation. The results suggest that treatment of fluoxetine will be useful in stem cells differentiation. Although this study should be further described possible mechanisms by which antidepressant, the serotonin trasporter can affect neural stem cell function, our contributions will be using to study and aid in stem cell trasplantation studies to found a cell-based therapeutic system for neurodegenerative disease.
Source: Alzheimer s & Dementia
Authors: Jeong-a Kim, Keun-A Chang, Yoo-Hun Suh
Institution: Seoul National University
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2006270949