Work

Methodological considerations with the use of urine samples for assessment of mercury excretion and markers of renal damage

Year: 2010

Type: article

Abstract: OBJECTIVE: To provide recommendations for design and analysis of studies using urine specimens to evaluate renal function or mercury excretion in children. METHODS: An analysis of mercury, albumin, γ-glutamyl transpeptidase (γ-GT) and N-acetyl-β-D-glucosaminidase (NAG) concentrations was carried out. RESULTS: Mercury concentration and creatinine-corrected renal markers were higher in daytime compared with overnight samples. Excretion rates increased with urinary flow rate. γ-GT and NAG concentrations decreased with storage time at -20°C. Differences by age, sex and race were noted. CONCLUSIONS: We recommend use of these creatinine-corrected markers and collection of timed overnight urine samples, stored at -70°C, with control for urinary flow rate, age, sex and race in statistical models.

Source: Biomarkers

DOI: 10.3109/1354750x.2010.510581

Authors: Felicia Trachtenberg, Lars Barregard, Nancy Maserejian, Sonja McKinlay

Institutions: New England Research Institutes, Sahlgrenska University Hospital

Language: English

Topic: Mercury impact and mitigation studies

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Dental and Craniofacial Research