Work

Cytokine generation by human basophils

Year: 1994

Type: review

Abstract: The concept that basophils and mast cells participate in acute allergic reactions is based in part on evidence from studies demonstrating the rapid release of inflammatory mediators including histamine, leukotrienes, and prostaglandins after the activation of these cells by various stimuli. The role that basophils play in complex allergic disease states is less well understood, yet might best be explained by their role in the “late phase response” (LPR) to antigen. After the description of this phenomenon in the early 1970s by Dolovich et al.

Source: Journal of Allergy and Clinical Immunology

DOI: 10.1016/0091-6749(94)90331-x

Authors: John T. Schroeder, Donald W. MacGlashan, Anne Kagey-Sobotka, Jane M. White, Lawrence M. Lichtenstein

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Mast cells and histamine

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,900