Cytokines Associated With Bronchopulmonary Dysplasia or Death in Extremely Low Birth Weight Infants
Year: 2009
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days. METHODS: For 1067 extremely low birth weight infants in the Neonatal Research Network of the National Institute of Child Health and Human Development, levels of 25 cytokines were measured in blood collected within 4 hours after birth and on days 3, 7, 14, and 21. Stepwise regression analyses using peak levels of the 25 cytokines and 15 clinical variables identified variables associated with bronchopulmonary dysplasia/death. Multivariate logistic regression analysis was performed for bronchopulmonary dysplasia/death by using variables selected through stepwise regression. Similar analyses were performed by using average cytokine values from days 0 to 21, days 0 to 3, and days 14 to 21. RESULTS: Of 1062 infants with available data, 606 infants developed bronchopulmonary dysplasia or died. On the basis of results from all models combined, bronchopulmonary dysplasia/death was associated with higher concentrations of interleukin 1beta, 6, 8, and 10 and interferon gamma and lower concentrations of interleukin 17, regulated on activation, normal T cell expressed and secreted, and tumor necrosis factor beta. Compared with models with only clinical variables, the addition of cytokine data improved predictive ability by a statistically significant but clinically modest magnitude. CONCLUSIONS: The overall cytokine pattern suggests that bronchopulmonary dysplasia/death may be associated with impairment in the transition from the innate immune response mediated by neutrophils to the adaptive immune response mediated by T lymphocytes.
Source: PEDIATRICS
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS, General Clinical Research Center, General Clinical Research Center, NICHD Cooperative Multicenter Neonatal Research Network, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, GENERAL CLINICAL RESEARCH CENTER, GENERAL CLINICAL RESEARCH CENTER, GENERAL CLINICAL RESEARCH CENTER, G2651334979, Multicenter Network of Neonatal Intensive Care Units, General Clinical Research Center, NICHD Cooperative Multicenter Neonatal Research Network, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, NICHD Cooperative Multicenter Neonatal Research Network, Cooperative Multicenter Neonatal Research Network, NICHD Cooperative Multicenter Neonatal Research Network, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, Multicenter Network of Neonatal Intensive Care Units, C-Reactive Protein in Extremely Low Birth Weight Neonates, General Clinical Research Center, Cooperative Multicenter Neonatal Research Network - UAB, MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS, General Clinical Research Center, Multicenter Network of Neonatal Intensive Care Units, General Clinical Research Center, G5961904166, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Cooperative Multicenter Network of Neontal Intensive Care Units, GENERAL CLINICAL RESEARCH CENTER, University of New Mexico - General Clinical Research Center, General Clinical Research Center, G8304734444, MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS, Data Ctr for the Cooperative Neonatal Research Network, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, NICHD Coooperative Multicenter Neonatal Research Network, G8953661689, NICHD Neonatal Research Network Clinical Center UAB, NICHD Neonatal Research Network - Stanford University
OpenAlex ID: W2006500041