Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
Year: 2013
Type: article
Abstract: Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological host responses that can lead to tissue injury and disease progression. Here, we summarize the role of type I IFNs in the regulation of cell death and disease during different microbial infections, ranging from viruses and bacteria to fungal pathogens. Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies.
Institution: St. Jude Children's Research Hospital
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G137859075, Role of IL-1alpha signaling in inflammatory diseases and host defense, G2851941416, G3789341260, G3831755428, G4533544333, G5372223083, Inflammatory Caspases in Innate Immunity and Inflammation, G8167955467, G9000196776, G9000290205, Inflammatory Caspases in Innate Immunity and Inflammation
OpenAlex ID: W2006720876