Work

Integrating with integrins.

Year: 1994

Type: article

Abstract: Our central claim is that signaling by integrins provides a mechanism by which signals generated in response to adhesion, soluble hormones, and mechanical forces can interact. Such interactions permit cells to integrate these different classes of external stimuli and hence to orchestrate an efficient response. This integrating function of integrins is likely to be essential for much of development and physiology, as well as complex pathologies such as cancer. Understanding in detail how these signals are transduced and processed is likely to be an important area of research in the near future.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.5.4.389

Authors: M A Schwartz, D E Ingber

Institution: Scripps Research Institute

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences

Awards: Regulation of Angiogenesis, CELL ADHESION MECHANISMS IN VASCULAR DISEASE, Mechanisms of mechanosensing through integrins