Year: 2014
Type: article
Abstract: OBJECTIVE: To determine whether an intensive lifestyle intervention (ILI) designed to sustain weight loss and improve physical fitness in overweight or obese persons with type 2 diabetes was associated with bone loss after 4 years of follow-up. RESEARCH DESIGN AND METHODS: This randomized controlled trial of intensive weight loss compared an ILI with a diabetes support and education (DSE) group among 1,309 overweight or obese subjects. Bone mineral density was assessed at baseline and after 1 year and 4 years of intervention. RESULTS: ILI was effective in producing significant weight loss (5.3% vs. 1.8% in ILI and DSE, respectively; P < 0.01) and increased fitness (6.4% vs. -0.8%) at year 4. In men, ILI participants had a greater rate of bone loss during the first year (-1.66% vs. -0.09% per year in ILI and DSE, respectively). Differences between groups were diminished by one-half after 4 years (-0.88% vs. -0.05% per year in ILI and DSE, respectively) but remained significant (P < 0.01). The difference in rate of hip bone loss between groups over 4 years was related to increased weight loss in ILI. Among women, the rate of bone loss did not differ between ILI and DSE after 4 years. CONCLUSIONS: A 4-year weight loss intervention was significantly associated with a modest increase in bone loss at the hip in men but not in women.
Source: Diabetes Care
DOI: 10.2337/dc14-0762
Institutions: University of Washington, VA Puget Sound Health Care System, University of California, San Francisco, Wake Forest University Health Sciences, Wake Forest University, University of Tennessee Health Science Center, Centers for Disease Control and Prevention, Pennington Biomedical Research Center, Louisiana State University, University of Pennsylvania, University of Southern California, University of Alabama at Birmingham
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1149464818, G1153163889, G1187123934, G1442900148, G1559150778, G1561916549, G1625418467, G1681235271, G1789861183, G1825392443, G1895210975, G1902398179, G2037811546, G2115812462, G215709867, G220748524, G2247787434, G2279102038, G241913450, G2456504948, G2469879864, G2519210884, G2875079641, G3033840998, G3041424743, G3085877500, 05/16 Action for Health in Diabetes Extension Study - Research Project, G3237517486, General Clinical Research Center, G3422150604, General Clinical Research Center, General Clinical Research Center, Institute for Integration of Medicine & Science: A Partnership to Improve Health, GENERAL CLINICAL RESEARCH CENTER, G3728863030, University of Pittsburgh Clinical and Translational Science Institute, G386878553, G4140582021, G4451789618, G4623107666, G474757791, G5085995034, 09/16 Action for Health in Diabetes Extension Study Research Project, 08/16 Action for Health in Diabetes Extension Study Research Project, 07/16 Action for Health in Diabetes Extension Study Research Project, G5800301348, G677419319, G7244940528, G7376939847, Obesity/Nutrition Research Center, 12/16 Action for Health in Diabetes Extension Study Research Project, G881343144, Diabetes Research Center, G900410922, G955307958, G980169708
OpenAlex ID: W2006876571