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Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

Year: 2010
Type: article
Study design: Observational Study
Abstract: C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R(2)=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.
Source: Biomarkers
DOI: 10.3109/1354750x.2010.509811
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: green
Funders: Ulster University, National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences, National Center for Research Resources, NIH Clinical Center, National Center for Advancing Translational Sciences, Medical Research and Materiel Command
Awards: G1008007976, Cellular Response Mechanisms to Environmental Challenge, G141707095, G2432115572, PHYTOESTROGENS AND BREAST CANCER PREVENTION, G502784552, Mammographic Density and Soy Isoflavones, UTMB Clinical and Translational Science Award, UTMB Clinical and Translational Science Award, General Clinical Research Center
OpenAlex ID: W2006879918
FWCI: 0.931
Cites: 38
Cited by: 16
Related to: 10