Molecule of the month, PDE4DIP
Year: 2012
Type: article
Abstract: The gene product, phosphodiesterase 4D (PDE4D) is anchored at the centrosome-Golgi cell region by phosphodiesterase 4D interacting protein (PDE4DIP). PDE4D is a member of a family of phosphohydrolyases. These enzymes are involved in signal transduction and hydrolyze 3 ' cyclic phosphate bonds in 3’, 5’-cGMP and 3’,5’-cAMP to energyze several reactions in the cell. The latter are termed second messengers and their rates of degradation are regulated. Eleven subtypes of PDEs comprise reactions related to memory and learning as well as other processes including immune cell activation, hormonesecretion, smooth vascular muscle action, platelet aggregation, and cardiac contractility [1]. Figure 1: PDE4DIPinteractions. In this figure, line-colors and various interactions with other genes are red Down-regulation, green Up-regulation, beige Regulation, purple Co-expression, brown Physical Interaction, turquoise dotted Predicted Protein Interaction, and mauve dotted Predicted TFactor Regulation.
Source: Bioinformation
Author: Paul Shapshak
Institutions: University of South Florida, Tampa General Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2006951641