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Caffeic Acid Protects Hydrogen Peroxide Induced Cell Damage in WI-38 Human Lung Fibroblast Cells

Year: 2006

Type: article

Abstract: Cytoprotective effect of caffeic acid (3,4-dihydroxy cinnamic acid) on human lung fibroblast (WI-38) cells against hydrogen peroxide induced damage was investigated. Caffeic acid was found to scavenge intracellular reactive oxygen species, and 1,1-diphenyl-2-picrylhydrazyl radical, and thus prevented lipid peroxidation. The caffeic acid protected cell damage of WI-38 cells exposed to hydrogen peroxide (H(2)O(2)), via the activation of extracellular signal regulated kinase protein. Caffeic acid increased the activity of catalase and its protein expression. Hence, from the present study, it is suggestive that caffeic acid protects WI-38 cells against H2O2 damage by enhancing the cellular antioxidant activity.

Source: Biological and Pharmaceutical Bulletin

DOI: 10.1248/bpb.29.1820

Authors: Kyoung Ah Kang, Kyoung Hwa Lee, Rui Zhang, Meijing Piao, Sungwook Chae, Kil Nam Kim, You Jin Jeon, Doek Bae Park, Ho Jin You, Jin Sook Kim, Jin Won Hyun

Institutions: Jeju National University, Chosun University, Korea Institute of Oriental Medicine

Language: English

Topic: Phytochemicals and Antioxidant Activities

Subfield: Biochemistry (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2007013247

FWCI: 1.206

Cites: 36

Cited by: 32

Related to: 10