Work

Growth Conditions Regulate the Requirements forCaulobacterChromosome Segregation

Year: 2008

Type: article

Abstract: Growth environments are important metabolic and developmental regulators. Here we demonstrate a growth environment-dependent effect on Caulobacter chromosome segregation of a small-molecule inhibitor of the MreB bacterial actin cytoskeleton. Our results also implicate ParAB as important segregation determinants, suggesting that multiple distinct mechanisms can mediate Caulobacter chromosome segregation and that their relative contributions can be environmentally regulated.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00862-08

Authors: Conrad W. Shebelut, Rasmus B. Jensen, Zemer Gitai

Institutions: Princeton University, Roskilde University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Energy, Office of Science

Awards: G222768804, DYNAMIC SPATIAL ORGANIZATION OF MULTI-PROTEIN COMPLEXES CONTROLLING MICROBIAL POLAR ORGANIZATION, CHROMOSOME REPLICATION, AND CYTOKINESIS, DYNAMIC SPATIAL ORGANIZATION OF MULTI-PROTEIN COMPLEXES CONTROLLING MICROBIAL POLAR ORGANIZATION, CH