Year: 2004
Type: article
Abstract: Senescence is a permanent form of cell cycle arrest that limits the proliferation of damaged cells and may contribute to tumor suppression and aging. We recently demonstrated that some senescent cell types undergo dramatic changes in chromatin organization that are dependent on the retinoblastoma protein and are associated with the stable repression of some E2F target genes. Here we show how these changes might contribute to the stability of the senescent state.
Source: Cell Cycle
DOI: 10.4161/cc.3.3.699
Authors: Masashi Narita, Scott W. Lowe
Institution: Cold Spring Harbor Laboratory
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Cancer Institute
Award: Cancer Center Support Grant
OpenAlex ID: W2007093903