Work

Effects of antipsychotic drugs on metabolite ratios in rat brain in vivo

Year: 2000

Type: article

Abstract: Localized in vivo proton magnetic resonance spectroscopy at 4.7 T was used to examine the brains of rats that were given the antipsychotic drugs haloperidol, clozapine, or olanzapine for 1 week. Spectra were collected before and during treatment. The ratios of N-acetylaspartate (NAA) to creatine (Cr) and choline to Cr were determined from the spectra. No significant differences in these ratios were seen among the rats given the various antipsychotic medications or between the control rats and the treated rats. No significant time-dependent changes were seen in most cases, except for a small reduction of NAA/Cr after 7 days of olanzapine administration. These results suggest that differences in brain metabolite ratios in vivo in schizophrenics relative to controls, at least for short-term treatment, arise from the disease, and not as a metabolic effect of the medication.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/(sici)1522-2594(200003)43:3<355::aid-mrm6>3.0.co;2-r

Authors: Diana M. Lindquist, Roger M. Hawk, Craig N. Karson, Richard A. Komoroski

Institutions: University of Arkansas at Little Rock, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Eli Lilly and Company