Immune system development during early childhood in tropical Latin America: Evidence for the age-dependent down regulation of the innate immune response
Year: 2011
Type: article
Study design: Observational Study
Abstract: The immune response that develops in early childhood underlies the development of inflammatory diseases such as asthma and there are few data from tropical Latin America (LA). This study investigated the effects of age on the development of immunity during the first 5 years of life by comparing innate and adaptive immune responses in Ecuadorian children aged 6-9 months, 22-26 months, and 48-60 months. Percentages of naïve CD4+ T cells declined with age while those of memory CD4(+) and CD8(+) T cells increased indicating active development of the immune system throughout the first five years. Young infants had greater innate immune responses to TLR agonists compared to older children while regulatory responses including SEB-induced IL-10 and percentages of FoxP3(+) T-regulatory cells decreased with age. Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology.
Source: Clinical Immunology
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,400
Awards: Impact of early infectious and microbial exposures on the development of immunity and allergic inflammatory disease in children living in a tropical region of Ecuador., Pilot cross-sectional study of differences in immune programming and immune development between infants and children living in urban and rural environments in Ecuador., Mucosal immunity and rectal challenge, Mucosal Epithelium and Long-Term Anti-Retroviral Therapy, Pilot cross-sectional study of differences in immune programming and immune development between infants and children living in urban and rural environments in Ecuador., The impact of urbanization, migration and changes in lifestyle and in exposure to infection on frequency of atopic diseases in Latin America, The impact of maternal and infant geohelminth infections on atopy and vaccine immunity in infants living in rural tropical region of Ecuador., CD4 T cells and anti-viral control in SIV infection
OpenAlex ID: W2007234139