Metabolism as an integral cog in the mammalian circadian clockwork
Year: 2013
Type: review
Abstract: Circadian rhythms are an integral part of life. These rhythms are apparent in virtually all biological processes studies to date, ranging from the individual cell (e.g. DNA synthesis) to the whole organism (e.g. behaviors such as physical activity). Oscillations in metabolism have been characterized extensively in various organisms, including mammals. These metabolic rhythms often parallel behaviors such as sleep/wake and fasting/feeding cycles that occur on a daily basis. What has become increasingly clear over the past several decades is that many metabolic oscillations are driven by cell-autonomous circadian clocks, which orchestrate metabolic processes in a temporally appropriate manner. During the process of identifying the mechanisms by which clocks influence metabolism, molecular-based studies have revealed that metabolism should be considered an integral circadian clock component. The implications of such an interrelationship include the establishment of a vicious cycle during cardiometabolic disease states, wherein metabolism-induced perturbations in the circadian clock exacerbate metabolic dysfunction. The purpose of this review is therefore to highlight recent insights gained regarding links between cell-autonomous circadian clocks and metabolism and the implications of clock dysfunction in the pathogenesis of cardiometabolic diseases.
Authors: Karen L. Gamble, Martin E. Young
Institutions: University of Alabama at Birmingham, UAB Medicine
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: National Institutes of Health, Center for Clinical and Translational Science, University of Alabama at Birmingham, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G2031771895, Circadian dysfunction and neurodegenerative disease, Integration of photic and nonphotic signaling in the circadian pacemaker, Time-of-Day-Dependent Feeding Influences Myocardial Function, Integration of photic and nonphotic signaling in the circadian pacemaker, Influence of the Cardiomyocyte Circadian Clock on Cardiac Hypertrophy, UAB Center for Clinical and Translational Science (CCTS) UL1, Role of the Molecular Circadian Clock within the Heart
OpenAlex ID: W2007270297