Work

On the attribution and additivity of binding energies

Year: 1981

Type: article

Abstract: It can be useful to describe the Gibbs free energy changes for the binding to a protein of a molecule, A-B, and of its component parts, A and B, in terms of the "intrinsic binding energies" of A and B, DeltaG(A) (i) and DeltaG(B) (i), and a "connection Gibbs energy," DeltaG(s) that is derived largely from changes in translational and rotational entropy. This empirical approach avoids the difficult or insoluble problem of interpreting observed DeltaH and TDeltaS values for aqueous solutions. The DeltaG(i) and DeltaG(s) terms can be large for binding to enzymes and other proteins.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.78.7.4046

Author: William P. Jencks

Institution: Brandeis University

Language: English

Topic: thermodynamics and calorimetric analyses

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2007272508

FWCI: 5.018

Cites: 34

Cited by: 948

Related to: 10