Year: 1971
Type: conference-abstract
Abstract: The methods used to record the cochlear potentials, stimulate the crossed olivo-cochlear bundle (COCB), and perfuse the scala tympani in guinea pigs were those described by Konishi [J. Acoust. Soc. Amer. 47, 1055–1062 (1970)]. Acetylcholine chloride (247 μM) and eserine sulfate (10 μM) when combined produced an inhibition of the action potential and an augmentation of the cochlear microphonics. The action potential and cochlear microphonics became insensitive to the continued presence of the drug combination. A second perfusion with the acetylcholine (247 μM)-eserine (10 μM) combination following a perfusion with artificial perilymph reproduced the “mimicking” response. A perfusion with curare (50 μM) together with acetylcholine (247 μM)-eserine (10 μM) following a perfusion with curare (50 μM) did not demonstrate a “mimicking” response. These data are consistent with hypotheses that the COCB is cholinergic. [Supported by a Public Health Service grant and an NIH fellowship from NDS.]
DOI: 10.1121/1.1977795
Authors: R. P. Bobbin, T. Konishi
Institution: University of Florida
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2007592140