Work

Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression

Year: 2014

Type: review

Abstract: Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with high prevalence of medical comorbidities and cognitive impairment. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Cytokines are proteins involved in the regulation and the orchestration of the immune response. We performed a review on the involvement of cytokines in BD. We also discuss the cytokines involvement in the neuroprogression of BD. It has been demonstrated that increased expression of cytokines in the central nervous system in postmortem studies is in line with the elevated circulating levels of proinflammatory cytokines in BD patients. The proinflammatory profile and the immune imbalance in BD might be regarded as potential targets to the development of new therapeutic strategies.

Source: Neural Plasticity

DOI: 10.1155/2014/360481

Authors: Izabela Guimarães Barbosa, Moisés Evandro Bauer, Rodrigo Machado-Vieira, Antonio Lucio Teixeira

Institutions: Universidade Federal de Minas Gerais, Pontifícia Universidade Católica do Rio Grande do Sul, National Institutes of Health, Universidade de São Paulo, National Institute of Mental Health

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,830