Work

Molecular dynamics study of the LS3 voltage‐gated ion channel

Year: 1998

Type: article

Abstract: Molecular dynamics calculations have been carried out on a model of the LS3 synthetic ion channel in a membrane mimetic environment. In the absence of an external electrostatic field, the LS3 channel, which consists of a bundle of six alpha-helices with sequence Ac-(LSSLLSL)3-CONH2, exhibits large structural fluctuations. However, in the presence of the field, the bundle adopts a well defined coiled-coil structure with an inner pore of water. The observed structural changes induced by the applied field are consistent with the proposed gating mechanism of the ion channel.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(98)00304-4

Authors: Qingfeng Zhong, Preston B Moore, Dennis M Newns, Michael L Klein

Institutions: University of Pennsylvania, IBM (United States), IBM Research - Thomas J. Watson Research Center

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: International Business Machines Corporation, National Institutes of Health, National Institute of General Medical Sciences

Awards: G1662424303, Computer Simulation of Amphiphilic Aggregates