Work

Evaluation of New Anti-Infective Drugs for the Treatment of Urinary Tract Infection

Year: 1992

Type: article

Abstract: The term urinary tract infection (UTI) encompasses a broad range of clinical entities that share one characteristic: a positive urine culture. Clinical manifestations and responses to therapy are diverse even when comparable numbers of a particular bacterial species are identified on urine culture. These guidelines include discussion of acute uncomplicated cystitis, acute uncomplicated pyelonephritis, and complicated infections of the urinary tract. It is proposed that the finding of > or = 10(3) cfu/mL of urine defines significant bacteriuria in acute uncomplicated cystitis, > or = 10(4) cfu/mL in acute uncomplicated pyelonephritis and UTI in men, and > or = 10(5) cfu/mL in complicated UTI. The preferred clinical study design is prospective, randomized, and controlled with an active agent. Ideally, treatment with antimicrobial agents should eradicate the infecting organism, bring about the resolution of clinical signs and symptoms, have few adverse effects, and prevent reinfection.

Source: Clinical Infectious Diseases

DOI: 10.1093/clind/15.supplement_1.s216

Authors: Robert H. Rubin, Eugene D. Shapiro, Vincent T. Andriole, Robert J. Davis, Walter E. Stamm

Institutions: Yale New Haven Hospital, Harvard University, Harborview Medical Center, Yale University, Massachusetts General Hospital

Language: English

Topic: Urinary Tract Infections Management

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Agency for Healthcare Research and Quality