Work

Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways

Year: 2008

Type: article

Abstract: Here we define the expression of approximately 100 transcription factors in progenitors and neurons of the developing basal ganglia. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 b-HLH transcription factor. These analyses define core transcriptional components that differentially specify the identity and differentiation of the striatum, nucleus accumbens, and septum.

Source: The Journal of Comparative Neurology

DOI: 10.1002/cne.21854

Authors: Jason E. Long, Christo Swan, Winnie S. Liang, Inma Cobos, Gregory B. Potter, John L.R. Rubenstein

Institutions: University of California, San Francisco, Translational Genomics Research Institute

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Mental Health