Work

Carrier-based Intralymphatic Cisplatin Chemotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head & Neck

Year: 2010

Type: article

Abstract: BACKGROUND: Since head and neck squamous cell carcinoma (HNSCC) preferentially metastasizes to the locoregional lymphatics, treatment of the tumor-draining cervical lymph nodes is paramount. RESULTS: We developed a hyaluronan-cisplatin (HA-Pt) nanoconjugate with prolonged lymphatic retention and greatly improved tumor tissue deposition for the treatment of metastatic HNSCC. We also developed an orthotopic metastatic xenograft model of HNSCC to examine the efficacy of the nanoconjugate. HNSCC (1/week x 3 weeks) were completely cured for 57% of the female mice in the HA-Pt treatment group, which demonstrated greatly hindered HNSCC progression compared with the standard cisplatin therapy (p < 0.05). CONCLUSION: With this insight, we will be able to optimize the carriers for better uptake, penetration and retention within cancer cells.

Source: Therapeutic Delivery

DOI: 10.4155/tde.10.38

Authors: Shuang Cai, Yumei Xie, Neal M Davies, Mark S Cohen, M Laird Forrest

Institutions: University of Kansas, Pacific Northwest National Laboratory, Washington State University, University of Kansas Medical Center

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Center for Research Resources