Year: 2011
Type: article
Abstract: Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed. Keywords: Hypoxia, Cancer, Molecular Imaging, Radiosynthesis, Fluorination, Fluorine-18, Copper-64, HIF-1, Carbonic Anhydrase IX, Positron Emission Tomography, Fluorescence, Single Photon Emission Computed Tomography
Source: Current Organic Synthesis
Institutions: Stanford Medicine, Stanford University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2008283713