Work

Stimulation of Mammalian Erythropoiesis by 5β-H Steroid Metabolites

Year: 1970

Type: article

Abstract: The effects of a number of steroid compounds on erythropoiesis in normal and polycythemic mice were examined. Of the steroids that stimulated erythropoiesis, the hormone testosterone and certain 5beta-H C(19) and C(21) nonhormonal metabolites were the most effective. Anti-erythropoietin abolished the erythropoiesis-stimulating effects of testosterone but not those exerted by the 5beta-H steroid, 11-ketopregnanolone. Similarly, testosterone but not 11-ketopregnanolone evoked the production of erythropoiesis-stimulating factor in rats. It is concluded that two mechanisms underlie the stimulating actions of steroids on erythropoiesis; one through the production of erythropoietin and the second involving a more direct influence on the blood-forming tissues. The 5beta-H steroid metabolites are postulated to act on erythropoiesis via the latter mechanism.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.65.4.919

Authors: Albert S. Gordon, Esmail D. Zanjani, Richard D. Levere, Attallah Kappas

Institutions: State University of New York, SUNY Downstate Health Sciences University, New York University, Rockefeller University

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2008338524

FWCI: 10.96

Cites: 21

Cited by: 91

Related to: 10