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Rhodium-Catalyzed Transannulation of 1,2,3-Triazoles with Nitriles

Year: 2008

Type: article

Abstract: Stable and readily available 1-sulfonyl triazoles are converted to the corresponding imidazoles in good to excellent yields via a rhodium(II)-catalyzed reaction with nitriles. Rhodium iminocarbenoids are proposed intermediates.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja805079v

Authors: Tony Horneff, Stepan Chuprakov, Natalia Chernyak, Vladimir Gevorgyan, Valery V. Fokin

Institutions: Scripps Research Institute, University of Illinois Chicago

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute on Drug Abuse, National Institute of General Medical Sciences

Awards: Resistance Driven Structural Design for HIV Therapies, Novel Direct Approaches Toward Bioactive Heterocycles, Nicotinic Receptor Template-guided Drug Design

OpenAlex ID: W2008409959

FWCI: 5.96

Cites: 32

Cited by: 521

Related to: 10