Work

Macrocyclic polyamines inhibit HIV infection by interacting with the cellular HIV co-receptors CXCR4 and CCR5

Year: 2009

Type: article

Abstract: Background A number of macrocyclic polyamines and/or their metal complexes are known to have anti-HIV activity. For example, CADA compounds are triazacyclododecanes that specifically down-modulate CD4, the principal cellular receptor for HIV. Bicyclams and their metal complexes act as entry inhibitors by a different mechanism, via specific binding to the cellular co-receptor CXCR4. Manganese(II) complexes of certain penta-azacyclo-pentadecanes are superoxide dismutase mimics and reduce oxidative stress in cells; one such compound, M40401, has been reported to decrease apoptosis in HIV-infected astrocytes.

Source: Retrovirology

DOI: 10.1186/1742-4690-6-s2-p80

Authors: Dominique Schols, Sunil Hamal, Li Cui, Dana Huskens, Stefano Aquaro, Thomas Bell

Institutions: Rega Institute for Medical Research, KU Leuven, University of Nevada, Reno, University of Rome Tor Vergata

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890