Antioxidant activity of Piper caninum and Cyclooxygenase-2 inhibition by methoxylated flavones.
Year: 2015
Type: article
Abstract: Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones.Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrationsKey words: Piper caninum; antioxidant; cyclooxygenase-2.List of abbreviations: COX-2, cyclooxygenase-2; DPPH, 2,2-diphenyl- 1-picrylhydrazyl; PGE2, prostaglandin E2.
Authors: MH Nadri, MA Naser, RM Zukifli, II Muhamad, F Ahmad, WMNHW Salleh, HM Sirat
Institution: University of Technology Malaysia
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
Funder: Universiti Teknologi Malaysia
Award: G1001717021
OpenAlex ID: W2009106763