Work

Immunologic strategies for HIV-1 remission and eradication

Year: 2014

Type: review

Abstract: Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals who have access to these medications, are able to tolerate these drugs, and are motivated to take them daily for life. However, ART is not curative. HIV-1 persists indefinitely during ART as quiescent integrated DNA within memory CD4(+) T cells and perhaps other long-lived cellular reservoirs. In this Review, we discuss the role of the immune system in the establishment and maintenance of the latent HIV-1 reservoir. A detailed understanding of how the host immune system shapes the size and distribution of the viral reservoir should lead to the development of a new generation of immune-based therapeutics, which may eventually contribute to a curative intervention.

Source: Science

DOI: 10.1126/science.1255512

Authors: Dan H. Barouch, Steven G. Deeks

Institutions: Beth Israel Deaconess Medical Center, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology, University of California, San Francisco

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases