Work

Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma

Year: 2013

Type: article

Abstract: Human papillomavirus (HPV) types associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role in the creation of an immunoprivileged site for viral persistence and the subsequent development of cancer.

Source: OncoImmunology

DOI: 10.4161/onci.24065

Author: Sara I. Pai

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913