Work

Biodegradable Micelles Capable of Mannose‐Mediated Targeted Drug Delivery to Cancer Cells

Year: 2015

Type: article

Abstract: A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.

Source: Macromolecular Rapid Communications

DOI: 10.1002/marc.201400650

Authors: Lichen Yin, Yongbing Chen, Zhonghai Zhang, Qian Yin, Nan Zheng, Jianjun Cheng

Institutions: Soochow University, Collaborative Innovation Center of Suzhou Nano Science and Technology, Second Affiliated Hospital of Soochow University, University of Illinois Urbana-Champaign

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Division of Chemistry