Work

Mesenchymal stem cells in immunoregulation

Year: 2006

Type: review

Abstract: Mesenchymal stem cells are present within the bone marrow cavity and serve as a reservoir for the continuous renewal of various mesenchymal tissues. Recent studies suggest that mesenchymal stem cells modulate immune reactions in vitro and escape from immune surveillance in vivo. We provide herein a discussion of issues including the current research progress on the in vitro interactions of mesenchymal stem cells with multiple subsets of immune cells (dendritic cells, T cells, B cells and NK cells), in vivo transplantation outcomes, the possible underlying mechanisms, future research directions as well as potential clinical implications.

Source: Immunology and Cell Biology

DOI: 10.1111/j.1440-1711.2006.01458.x

Authors: Xi Chen, Marilyn Ann Armstrong, Gang Li

Institutions: Queen's University Belfast, Musgrave Park Hospital, Royal Victoria Hospital

Language: English

Topic: Mesenchymal stem cell research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Universities UK