Year: 2008
Type: article
Abstract: It is shown that biological networks with serial regulation (each node regulated by at most one other node) are constrained to direct functionality, in which the sign of the effect of an environmental input on a target species depends only on the direct path from the input to the target, even when there is a feedback loop allowing for multiple interaction pathways. Using a stochastic model for a set of small transcriptional regulatory networks that have been studied experimentally, it is further found that all networks can achieve all functions permitted by this constraint under reasonable settings of biochemical parameters. This underscores the functional versatility of the networks.
Source: IET Systems Biology
Authors: A. Mugler, E. Ziv, I. Nemenman, C.H. Wiggins
Institutions: Columbia University, Los Alamos National Laboratory
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2009757163