Work

Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity

Year: 2005

Type: article

Abstract: Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhibited phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0506184102

Authors: Adam C. Resnick, Adele M. Snowman, Bingnan N. Kang, K. Joseph Hurt, Solomon H. Snyder, Adolfo Saiardi

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University College London

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: National Institute on Drug Abuse

Awards: Drug Abuse Research Center, G979888002