Work

Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

Year: 2014

Type: article

Abstract: Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.

Source: The Analyst

DOI: 10.1039/c4an00667d

Authors: Brandon W. Heimer, Tatyana A. Shatova, Jungkyu K. Lee, Kaja Kaastrup, Hadley D. Sikes

Institutions: Massachusetts Institute of Technology, Kyungpook National University

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Science Foundation, National Institutes of Health, National Institute of Environmental Health Sciences