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Severe Hemolytic Transfusion Reaction Due to Anti-D in a D+ Patient With Sickle Cell Disease

Year: 2014

Type: article

Abstract: A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.

Source: Journal of Pediatric Hematology/Oncology

DOI: 10.1097/mph.0000000000000241

Authors: Tina S. Ipe, Jennifer J. Wilkes, Helge D. Hartung, Connie M. Westhoff, Stella T. Chou, David F. Friedman

Institutions: Houston Methodist, Children's Hospital of Philadelphia, New York Blood Center

Language: English

Topic: Blood groups and transfusion

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development