Work

Breast cancer: Small molecules targeting apoptosis, a prospective approach to safe scientific success

Year: 2012

Type: article

Abstract: Breast carcinoma represents the second leading cause of cancer death in developed countries amongst women. Current cytotoxic chemotherapy plays an important role in the management of patients with hormone-insensitive or metastatic breast carcinoma, although most of them ultimately develop recurrences. Therefore, there is a need for novel targets and treatment strategies in patients with advanced breast carcinoma that is refractory to conventional chemotherapy. This paper summarizes current knowledge on breast cancer targets and molecular mechanisms that follows apoptosis induction.

Source: Advances in Bioscience and Biotechnology

DOI: 10.4236/abb.2012.37104

Authors: Mpho Choene, Nonkululeko Mthembu, Zodwa Dlamini, Matlou Mokgotho, James Wachira, Lesetja Motadi

Institutions: University of the Witwatersrand, University of South Africa, University of Limpopo, Morgan State University

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Research Foundation