Work

Status and Prospects for Discovery and Verification of New Biomarkers of Cardiovascular Disease by Proteomics

Year: 2011

Type: article

Abstract: Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate new biomarkers and pathways without a prior known association with cardiovascular disease; however, important obstacles remain. In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes.

Source: Circulation Research

DOI: 10.1161/circresaha.110.225003

Authors: Robert E. Gerszten, Aarti Asnani, Steven A. Carr

Institutions: Broad Institute, Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology

Language: English

Topic: Advanced Proteomics Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Heart, Lung, and Blood Institute