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Comparable and Robust Immune Reconstitution after HLA-Haploidentical or HLA-Matched Allogeneic Transplantation (BMT) Utilizing Posttransplantation Cyclophosphamide

Year: 2015
Type: article
Abstract: Posttransplantation cyclophosphamide (PTCy) limits severe acute and chronic graft-versus-host disease (GVHD) and facilitates engraftment, permitting HLA-matched donor (MD) BMT without additional GVHD prophylaxis and the safe performance of HLA-haploidentical (haplo) BMT. Low rates of transplant related mortality, infection, and post-transplant lymphoproliferative disorders (PTLD) support that PTCy based immunosuppression allows favorable immune recovery. However limited data exist regarding immune reconstitution after haplo or MD BMT utilizing PTCy.
DOI: 10.1016/j.bbmt.2014.11.075
Authors: Shannon R. McCurdy, Ante Vulic, Heather J. Symons, Andrea M. Towlerton, Ben C. Valdez, Richard J. Jones, Ephraim J. Fuchs, Paul V. O'Donnell, Edus H. Warren, Christopher G. Kanakry, Leo Luznik
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2009978235
FWCI: 0.227
Cites:
Cited by: 9
Related to: 10