Strategic Plan for Pediatric Respiratory Diseases Research: An NHLBI Working Group Report
Year: 2009
Type: article
Abstract: The Division of Lung Diseases of the National Heart, Lung, and Blood Institute (NHLBI) recently held a workshop to identify gaps in our understanding and treatment of childhood lung diseases and to define strategies to enhance translational research in this field. Leading experts with diverse experience in both laboratory and patient-oriented research reviewed selected areas of pediatric lung diseases, including perinatal programming and epigenetic influences; mechanisms of lung injury, repair, and regeneration; pulmonary vascular disease; sleep and control of breathing; and the application of novel translational methods to enhance personalized medicine. This report summarizes the proceedings of this workshop and provides recommendations for emphasis on targeted areas for future investigation. The priority areas identified for research in pediatric pulmonary diseases included: (1) epigenetic and environmental influences on lung development that program pediatric lung diseases; (2) injury, regeneration, and repair in the developing lung; (3) pulmonary vascular disease in children; (4) development and adaptation of ventilatory responses to postnatal life; (5) nonatopic wheezing: aberrant large airway development or injury?; (6) strategies to improve assessment, diagnosis, and treatment of pediatric respiratory diseases; and (7) predictive and personalized medicine for children.
Authors: Mario Castro, Maria I. Ramirez, James E. Gern, Garry Cutting, Greg Redding, James S. Hagood, Jeffrey Whitsett, Steve Abman, J. Usha Raj, Robyn Barst, Gregory J. Kato, David Gozal, Gabriel G. Haddad, Nanduri R. Prabhakar, Estelle Gauda, Fernando D. Martinez, Robert Tepper, Robert E. Wood, Frank Accurso, W. Gerald Teague, Jose Venegas, F. Sessions Cole, Rosalind J. Wright
Institutions: Washington University in St. Louis, Boston University, University of Wisconsin–Madison, Johns Hopkins University, Johns Hopkins Medicine, Seattle Children's Hospital, University of Alabama, University of Alabama at Birmingham, Cincinnati Children's Hospital Medical Center, University of Colorado Anschutz, University of Colorado Denver, University of Illinois Chicago, Columbia University, National Institutes of Health, National Heart, Lung, and Blood Institute, University of Louisville, University of California San Diego, University of Chicago, University of Arizona, Indiana University School of Medicine, Indiana University, Emory University, Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2010138143