Work

Introduction of the 3-Deoxy Group in 3,6-Dideoxyhexoses: A Novel Cofactor Function for Pyridoxamine-5′-Phosphate

Year: 1972

Type: article

Abstract: A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5'-phosphate. Moreover, authentic pyridoxamine-5'-phosphate substituted for the purified cofactor with about the same specific activity. Other vitamin B(6) derivatives did not stimulate the reaction, and inhibition was observed with some of them.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.69.6.1625

Authors: Pedro Gonzalez-Porque, Jack L. Strominger

Institutions: Harvard University, Hospital Universitario Puerta de Hierro Majadahonda

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2010260474

FWCI: 0.587

Cites: 6

Cited by: 11

Related to: 10