Work

SIRT3 and cancer: Tumor promoter or suppressor?

Year: 2011

Type: review

Abstract: Sirtuins (SIRT1-7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer.

Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

DOI: 10.1016/j.bbcan.2011.04.004

Authors: Turki Y. Alhazzazi, Pachiyappan Kamarajan, Eric Verdin, Yvonne L. Kapila

Institutions: University of Michigan, University of California, San Francisco

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,070